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1.
Pakistan Journal of Medical Sciences. 2018; 34 (4): 950-954
in English | IMEMR | ID: emr-199119

ABSTRACT

Objective: To determine the levels of serum thyroxine [T3,T4], triiodothyronine and thyrotropin in patients with acute myocardial infarction [AMI]


Methods: It was an observational prospective study and 60 patients [both males and females] of AMI, [diagnosed by ECG and cardiac enzymes.] were included. Serum thyroid stimulating hormone [TSH], Free T3 and Free T4 were measured and relevant data was entered into a predesigned proforma


Results: FT3 levels were below the reference range in 56.7% cases while both the FT4 and TSH values were found to be the lower limit of normal range. When the decrease in FT3 was correlated with the duration of illness, it was found that significant inverse correlation existed between FT3 value and the duration of illness and linear regression line was obtained. No such correlation existed between FT4 and TSH values


Conclusion: Thyroid hormone levels [FT3] decreases in AMI and this change is associated with the duration of illness

2.
Pakistan Journal of Medical Sciences. 2017; 33 (6): 1459-1462
in English | IMEMR | ID: emr-189406

ABSTRACT

Background and Objective: Smoking Cessation Clinics [SCCs] involve the use of cognitive behavior therapy and effective medications provided by specialists. Our objective was to report socio-demographic data, investigative services provided, and determine the smoking cessation success


Methods: Data from all hospitals affiliated with the Beyoglu Public Hospitals Union were obtained between January 1, 2015 and December 31, 2015. Data from Sisli Hamidiye Etfal Training and Research Hospital were reviewed via retrospective chart review in the same period. Frequency and average values were determined using statistical software. In the evaluation of related factors, chi-square and student t tests were applied; p

Results: The mean admission age was 38.72 +/- 12.20 years [min 13; max 94]. Women tended to be older than men at the time of admission but men started smoking younger than women. Less than the high school educated subjects started smoking at early ages. The smoking cessation rate was 39.3% [n = 219] when treated with medication and behavioral therapy


Conclusion: About 48% smokers stopped smoking after treatment with medications and behaviour therapy. Most of the smokers were between 30-50 years of age. More Smoking Cessation Clinics should be established to allow access to more highly educated patients to smoking cessation resources

3.
Pakistan Journal of Medical Sciences. 2017; 33 (6): 1479-1484
in English | IMEMR | ID: emr-189410

ABSTRACT

Objective: Overweight or obesity may cause many chronic illnesses. Furthermore, several studies have shown that high body mass index is associated with mortality and morbidity among the elderly. Therefore, obesity or being overweight could adversely affect the performance of activities of daily living. In this study our aim was to investigate the association between Body Mass Index and Activity of Daily Living in Homecare Patients


Method: The records of 2016 from the homecare unit of Sisli Hamidiye Etfal Training and Research Hospital were retrospectively reviewed. During this period, 1105 patients visited this facility. Unconscious or bedridden patients [hemiplegia, hemiparesia, and tetraparesis] and patients with incomplete data were excluded from the study. Therefore, the survey was completed with 250 files, which included all the data needed for our research. Age, gender, Body Mass Index and Barthel Index scores were recorded to the statistical program; p

Results: One hundred fifty one [60.4%] were women, and 99 [39.6%] were men. The relations between gender and age, weight, and Barthel index scores were not statistically significant. There was a significant positive correlation between weight and Barthel index scores as well as between Body Mass Index and Barthel index scores [r = 0.190; p = 0.003]. The patients were divided into two groups: Group-I [underweight and normal weight] and Group-II [overweight and obese]. Group-II exhibited a much higher ability to perform Activity of Daily Living than Group-I [p = 0.002]


Conclusion: Some studies report that obesity is protective against Activity of Daily Living, but the opposite is reported in some others. Our study showed increased values of Body Mass Index and Activity of Daily Living ability, which are indicative of protective effects. The relationship between Body Mass Index and physical disability is not yet proven to be linear

4.
Pakistan Journal of Physiology. 2017; 13 (2): 41-43
in English | IMEMR | ID: emr-197561

ABSTRACT

Background: Idiopathic thrombocytopenic purpura [ITP] is a rare autoimmune disease characterized by the platelet destruction that is autoantibody mediated, and there is suboptimal platelet production in the absence of a known cause, this leads to decreased peripheral blood platelet counts or thrombocytopenia and Helicobacter pylori has direct association with ITP. The aim of this study was to see the platelet recovery in patients of ITP after the H. pylori infection eradication


Methods: This was a case control study and 120 ITP patients who tested positive for H. pylori [divided into age and sex matched treatment and the control groups] were enrolled from the outdoor patients [OPD] of Sheikh Zayed Medical Complex. Stool antigen [HpSA] enzyme immunoassay method [EIA] method was used for H. pylori detection


Results: The response of the platelet count in the treatment group was a 'complete response' in 35 [60.3%] patients, a partial response in 16 [27.6%] patients and no response was found in 7 [12.1%] cases. However, no remarkable change was seen in the platelet counts of the patients in the control group


Conclusion: Complete eradication of H. pylori helps in the recovery of H. pylori induced platelet reduction and detection and eradication of H. pylori infection should be considered in the work-up of patients with ITP

5.
Professional Medical Journal-Quarterly [The]. 1998; 5 (3): 357-62
in English | IMEMR | ID: emr-49454

ABSTRACT

The present study was designed to see the effect of 13-cis retinoic acid [CRA] on albino rats skin tumour initiation by dimethylbenze [a] anthracene [DMBA] and promotion by 12-"o" tetra decanoyl-phorbol. 13 acetate [TPA]. Skin tumour was initiated by 20 [micro] g/2.0 ml DMBA twice a week in one group of rats. In an other group of rats tumour promoter TPA was applied in a dose of 2[micro]/0.2m1, after the application of initiator [DMBA] in the same dose twice a week. This study was continued for 20 weeks. In another groups of rats I 3-cis retinoic acid [CRC] was applied before the application of initiator [DMBA] and promoter [TPA]. Topical application of CRA resulted in 80% tumour inhibition when given before the DMBA and 70% when given before TPA. The results indicate that vitamin 'A" [CRA] inhibits both stages of tumour initiation and promotion


Subject(s)
Animals, Laboratory , Isotretinoin/pharmacology , /pharmacology , Tetradecanoylphorbol Acetate/pharmacology , Rats , Skin Neoplasms/drug therapy , Vitamin A
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